Laparoscopic sleeve gastrectomy (LSG) is a restrictive procedure, although irreversible which is first described by Hess and Marceau in 1988. Then it was used in super-obese patients as the first step prior to other complex procedures. However in 1993, Johnston et al. proposed LSG as single procedure. Since then, LSG has gained popularity because it is considered a technically less complex procedure with satisfactory short-term results. Recent reports recommend LSG as a definitive treatment for morbid obesity with good results in excess weight loss and a favorable impact on comorbidities. The aim of this study was to compare the short- and midterm results in obese patients who underwent LRYGB versus LSG. The primary endpoint was weight loss. Secondary endpoints were short- and long-term complication rates, length of hospital stay, need for re-operation, and efficiency of the procedures inducing resolution of comorbidities.